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Manhattan-based psychotherapist Jonathan Alpert told Fox News on Friday that "Trump Derangement Syndrome" (TDS) is a real psychological issue he has seen firsthand in his practice, with three-quarters of his patients exhibiting symptoms.

During an interview with "The Faulkner Focus," Alpert said patients have come into his office exhibiting symptoms of mental distress stemming from their fear or anger toward President Donald Trump .

"This is a profound pathology, and I would even go so far to call it the defining pathology of our time," Alpert said.

TDS is a term generally used by Trump supporters to disparage what they view as hysterical or irrational critics of the president.

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