An NFC West clash is one of the late-afternoon games for Week 11 of the NFL season when the Arizona Cardinals host the San Francisco 49ers. The 49ers are 6-4 and are coming off a loss to the Los Angeles Rams, while the Cardinals are 3-6 after losing to the Seattle Seahawks. San Francisco won this matchup back in Week 3 by a final score of 16-15.

Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.

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