The San Francisco 49ers face the Arizona Cardinals in Week 11 of the NFL season on Sunday at State Farm Stadium.

How to Watch 49ers vs Cardinals

When: Sunday, November 16, 2025

Time: 4:05 PM ET

TV Channel: FOX

Live Stream: Fubo ( try for free )

The San Francisco 49ers come in as the stronger team, with a balanced offense that leans on their rushing and efficient short-to-intermediate passing game. Mac Jones has been leading the charge, but Brock Purdy returns to the lineup, and a healthy Christian McCaffrey has given them a reliable weapon both on the ground and through the air. On defense, losing Nick Bosa to a season-ending knee injury has been a big blow, but the 49ers are relying on younger pass-rushers to step up and their front seven to generate pressure and close running

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