The 49ers beat the Cardinals on Sunday 44-22, dominating their NFC West opponents in Arizona.

San Francisco led wire-to-wire after Skyy Moore returned the opening kickoff for 98 yards to set up a 1-yard touchdown by Christian McCaffrey on the first play from scrimmage.

McCaffrey had three touchdowns on the day (two rushing, one receiving) and 81 yards rushing on 13 carries.

George Kittle added two touchdowns along with his 67 yards on six catches.

Brock Purdy, in his return from a toe injury that has kept him out since the end of September, was 19-of-26 for 200 yards with three touchdowns and no interceptions.

The Niners had three takeaways, as well: interceptions by Malik Mustapha and Deommodore Lenoir and a fumble forced by Upton Stout.

Here’s what the 49ers said after the win:

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