CHARLOTTE — The Panthers (6-5) are back in prime time this week, for the first time in two years. It will require traveling to the West Coast to face the San Francisco 49ers (7-4).

This will be the first time the two teams have faced each other since October 2022, and the first time since 2019 that the Panthers will travel to San Francisco. The Panthers are 13-10 all-time against the 49ers, going back to the early days when the Panthers were in the NFC West (1995-2001). Carolina is 6-6 at home and 7-4 on the road at the 49ers.

From a return at quarterback, questions at kicker, and a reunion with an old friend, get to know the 2025 San Francisco 49ers ahead of Monday night's game.

A reunion with CMC

One 49ers player who Panthers' fans know very well already is Christian McCaffrey. The r

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