Over the past decade, Open Philanthropy has been the rare philanthropic shop with both the resources and the rigor to make a dent in some of the world’s biggest problems.

Working closely with Good Ventures — the charity built by Facebook and Asana co-founder Dustin Moskovitz and his wife Cari Tuna — Open Philanthropy has directed more than $4 billion since 2014 across a wide portfolio, from global health to housing to frontier science. Its money has backed philanthropic efforts estimated to have saved 100,000 lives, helped catalyze the YIMBY movement in California, fought to improve conditions for billions of farmed animals, and supported research that went on to win a Nobel Prize.

Whatever you think about “effective” giving as a label — or effective altruism, the movement that Open Phil

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