This Manhattan neighborhood might be losing its bohemian bona fides — one eight-figure sale at a time.

The Upper West Side has racked up two sky-high sales in recent weeks, one of which broke a neighborhood record, all thanks to a massive luxury development.

They reflect a prominent shift in the uptown enclave. Once the domain rent-controlled apartment blocks filled with writers and artists, the historic neighborhood is attracting an ever-wealthier set.

Extell Development Company changed the Upper West Side’s skyline when it constructed 50 W. 66th Street. If the name Extell sounds familiar, that’s because it’s the developer behind Central Park Tower and One57 on Billionaires’ Row.

On Monday, according to records filed with the city Department of Finance, a 50 W. 66th St. unit traded

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