The Jacksonville Jaguars (6-4) look to win their third in four games, including two in a row, when they take on the Arizona Cardinals (3-7) in Week 12 on Paramount+ . The Jaguars, second in the AFC South, are two games behind first-place Indianapolis. The Cardinals, meanwhile, are fourth in the NFC West, but are 3.5 games out of the final playoff spot in the conference. Trevor Lawrence and the Jaguars are coming off a 35-6 win over the Los Angeles Chargers, while the Cardinals were throttled 41-22 by San Francisco on Sunday.

Kickoff from State Farm Stadium in Glendale, Ariz., is set for 4:05 p.m. ET on CBS and Paramount+ . Jacksonville is a 2.5-point favorite in the latest Jaguars vs. Cardinals odds from SportsLine consensus, while the over/under for total points scored is 47.5.

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