Christian McCaffrey #23 of the San Francisco 49ers. Photo by Mike Christy/Getty Images Getty Images Gambling content 21+. The New York Post may receive an affiliate commission if you sign up through our links. Read our editorial standards for more information.

The 49ers and Panthers collide on “ Monday Night Football ,” as Christian McCaffrey takes a trip down memory lane.

CMC will take the field donning red and gold as an opponent, lining up for the first time against the team that selected him eighth overall in the 2017 NFL Draft.

San Francisco is a 7.5-point favorite in this contest. Oddsmakers have McCaffrey’s odds of hitting pay dirt juiced as high as -370 at some sportsbooks.

Panthers vs. 49ers odds, prediction

After starting the season 0-3 on the road, the Panthers have

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