Researchers at Weill Cornell Medicine and Wake Forest University School of Medicine have identified an immune-cell–driven molecular pathway that drives chemotherapy-induced peripheral neuropathy (CIPN), a common and treatment-limiting side effect of chemotherapy treatments. The study, published in Science Translational Medicine , suggests that CIPN may not originate in neurons, as widely assumed, but in circulating and dorsal root ganglion (DRG), myeloid cells that respond to chemotherapy with an inflammatory stress reaction.

The new findings are different from current thinking that CIPN is caused by microtubule stabilization and mitochondrial dysfunction within sensory neurons. While the researchers noted these still play a part, these new findings indicate that immune cells sense

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