What to Know

Programming note: Before the 49ers play the Panthers on "Monday Night Football" at Levi's Stadium, tune into " 49ers Pregame Live " at 4 p.m. PT on NBC Sports Bay Area or stream the show in the NBC Sports app for a full game preview with Carlos Ramirez, Rod Brooks and Matt Maiocco.

The San Francisco 49ers (7-4) welcome the Carolina Panthers (6-5) to the Bay for a prime-time Week 12 game.

Running back Christian McCaffrey will face his former team for the first time since Carolina dealt him to San Francisco at the 2022 NFL trade deadline in exchange for the 49ers' 2023 second, third and fourth-round draft picks, plus a 2024 fifth-rounder.

With Eddy Piñeiro sidelined by a hamstring injury, the 49ers elevated newly signed kicker Matt Gay from the practice squad to play a

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