Matt's quarterback (QB) fantasy football start 'em, sit 'em picks for Week 13 of 2025. His QB lineups advice for Week 13 fantasy football start/sit decisions.

With Thanksgiving this week, all 32 teams have dinner dates scheduled, so fantasy managers do not need to look for replacements for players on bye, but will need to break down this week's slate of matchups to gain an upper hand in what could be a pivotal point in the championship quests.

Last week, fantasy managers found serviceable replacements at the quarterback position in Jameis Winston and Cam Ward , whose performances earned them a spot in the top five for Week 12. At the same time, Lamar Jackson and Baker Mayfield failed to top eight fantasy points themselves. Now, the question is: who will be the turkey this week?

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