The Cleveland Browns opened as 5.5-point underdogs at home against the San Francisco 49ers ahead of their Week 13 match-up, according to FanDuel Sportsbook. The over/under on the game is 38.5.

The Browns (3-8) are coming off of a 24-10 victory over the Las Vegas Raiders, which saw Shedeur Sanders win his first career start, the defense register 10 sacks, and the special teams unit come through with a couple of big plays. Cleveland finally won a road game, and got the Raiders to fire their offensive coordinator after the game. Was this a flash in the pan, or a sign of things to come for the Browns to finish the 2025 season strong?

The 49ers (8-4) are coming off of a 20-9 win over the Carolina Panthers on Monday Night Football. It was a bit of a messy game, as Brock Purdy threw three first

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