The Notre Dame Fighting Irish (5-2) and No. 2 Houston Cougars (6-1) meet Wednesday in the Players Era Festival from MGM Grand Garden Arena in Las Vegas, Nevada. Tip is set for 3:30 p.m. ET (TNT). Let's analyze BetMGM Sportsbook's NCAA basketball odds around the Notre Dame vs. Houston odds and make our expert college basketball picks and predictions for the best bets.

Notre Dame lost its opener in the event 71-61 to the Kansas Jayhawks Monday, failing to cover as a 5.5-point underdog. It then took down the Rutgers Scarlet Knights 68-63 Tuesday, again failing to cover as a 7-point neutral-court favorite as the Under (141) cashed. Notre Dame is 3-4 against the spread (ATS), and 1-1 ATS as an underdog.

Houston beat the Syracuse Orange 78-74 in overtime Monday, failing to cover as a

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