The Hoosiers celebrate after the Indiana versus Wisconsin football game at Memorial Stadium on Saturday, Nov. 15, 2025.

The final week of the regular season is here and it is also rivalry week. Friday night the Indiana Hoosiers will head to West Lafayette, IN to take on the Purdue Boilermakers.

The Hoosiers come in a perfect 11-0 on the season and are ranked No. 2 in the country. They have all be secured a spot in the CFP and with a win will play for the Big Ten Championship next week.

The Boilermakers are on the opposite side of the Big Ten standings, as they have yet to win a conference game and come into Friday night 2-9.

If you're looking to get back in the swing of football season and need some betting advice for Friday's matchup in West Lafayette, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Purdue vs Indiana game odds:

All college football odds via BetMGM

  • Spread: Indiana -28.5 (-115), Purdue +28.5 (-105)
  • Money Line: Indiana -10000, Purdue +1800
  • Over-Under: Over 54.5 (-105), Under 54.5 (-115)

Purdue vs Indiana prediction, pick:

The Hoosiers have been dominant all season, and it doesn't look like it is going to stop on Friday. The Boilermakers have been struggling to stop anybody this season, and they are going to show little resistance to the Hoosiers. The line is high, but it isn't going to matter. The Hoosiers could also hit the over by themselves. This is going to be the second straight year the Hoosiers blow out the Boilermakers.

Prediction: Indiana 52, Purdue 10

Best Bet: Indiana -28.5, Over 54.5

Purdue vs Indiana channel, start time, streaming:

Time: 7:30 p.m. ET

TV Channel: Peacock

Live Stream: Peacock App

Stream Purdue vs. Indiana

Get more betting analysis and predictions at Sportsbook Wire.

This article originally appeared on College Sports Wire: Purdue vs Indiana: Week 14 College Betting Odds, Prediction, Pick

Reporting by Adam Childs, College Sports Wire / College Sports Wire

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