Via Coley Cleary, USA TODAY SMG

Week 14 can present unique opportunities. Some teams are playing for everything, while others likely can't wait for the season to wrap up.

That may be the case in an SEC game this weekend as the Oklahoma Sooners (9-2, 5-2 SEC), who need a win to essentially clinch a College Football Playoff berth, host the LSU Tigers (7-4, 3-4 SEC), who are amid a disappointing season, from Memorial Stadium in Norman, Oklahoma.

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

LSU vs. Oklahoma game odds:

All college football odds via BetMGM

  • Spread: Oklahoma -10 (-110), LSU +10 (-110)
  • Money Line: Oklahoma -375, LSU +300
  • Over-Under: Over 37.5 (-105), Under 37.5 (-115)

LSU vs. Oklahoma prediction, pick:

LSU can't wait to get out of 2025. It has been a nightmare for them, and if we are being honest, this looked like a team that was somewhere between sleepwalking and quitting last week when they barely escaped Western Kentucky 13-10.

Oklahoma has so much more to play for in this game, and they are going to come prepared. I'm not sure the Sooners' offense is potent enough to do a ton of damage in this game or the College Football Playoff, but the defense should be able to put the clamps on LSU and keep them stuck in the mud all day.

In front of a home crowd that can sense the moment, John Mateer steps up and leads Oklahoma to a win that punches a real-time ticket to the College Football Playoff.

Prediction: Oklahoma 24, LSU 10

Best Bet: Oklahoma -10

LSU vs. Oklahoma channel, start time, streaming:

Time: 3:30 p.m. ET

TV Channel: ABC

Live Stream: ESPN App

Watch LSU vs. Oklahoma on FuboTV (Free Trial)

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: LSU vs. Oklahoma: College Football Betting Odds, Prediction

Reporting by Riley Donald, College Sports Wire / College Sports Wire

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