The 2025 Palmetto Bowl unfolds Saturday when the South Carolina Gamecocks host the Clemson Tigers. It's been a disappointing season for both sides with South Carolina entering at 4-7 and Clemson at 6-5. The Tigers, however, have some momentum as they enter this matchup on a three-game winning streak. Clemson leads this series 73-44-4, though South Carolina has won two of the last three.

Kickoff is at noon ET from Williams-Brice Stadium. The Gamecocks are 2.5-point favorites in the latest South Carolina vs. Clemson odds, while the over/under is 46.5. Before making any Clemson vs. South Carolina picks, check out the college football predictions from the SportsLine Projection Model .

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