Final Four teams from last year will meet in the ACC/SEC Challenge 2025 as the No. 15 Florida Gators visit the No. 4 Duke Blue Devils on Tuesday. Florida (5-2) is the defending national champion but has as many losses through seven games as it had through 20 games last season, though the Gators are 2-0 versus ACC teams in 2025-26. Duke (8-0) has already defeated two SEC teams this season, the first coming in its season opener versus Texas, as well as its last game against Arkansas.

Tipoff is at 7:30 p.m. ET from Cameron Indoor Stadium in Durham, N.C. The Blue Devils are 8.5-point favorites in the latest Florida vs. Duke odds, while the over/under is 156.5. Before making any Duke vs. Florida picks, check out the men's college basketball predictions and betting advice from the SportsL

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