Amy Schumer went from a hustling stand-up comedian to a major movie star.

“After my dad got MS and we went bankrupt and my mom left him, that period from age 12 to 15 was a really rough time,” Schumer recalled to GQ in a 2015 profile. “And we all suffered from it, my siblings and I.”

As a way to help make ends meet, Schumer started performing comedy sets.

Schumer settled down in 2018, marrying chef Chris Fischer after a few months of dating. They welcomed their son, Gene, the next year.

In 2022, Schumer kickstarted a years-long health journey by undergoing liposuction. She later revealed a battle with Cushing syndrome, a condition where the body has too much cortisol, sharing in December 2025 that she lost 50 pounds as a way to “survive” the disease.

Schumer’s weight loss journey was

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