Head Coach John Calipari of the Arkansas Razorbacks. Getty Images Gambling content 21+. The New York Post may receive an affiliate commission if you sign up through our links. Read our editorial standards for more information.

The No. 6-ranked Louisville Cardinals will have the national TV spotlight shining on them when they face the No. 25-ranked Arkansas Razorbacks on ESPN Wednesday night.

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This is the first time this season the Cardinals will face a ranked opponent, while the Razorbacks have fallen to No. 22 Michigan State and No. 4 Duke already this season.

Louisville enters the game as 2.5-point

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