In a landmark effort to decode the cellular roots of childhood neurodevelopmental disorders (NDDs), researchers have built one of the largest publicly available stem-cell resources of its kind—an expansive biobank of induced pluripotent stem cells (iPSCs) and human brain organoids derived from genetically diverse patients. The atlas, published in Cell Stem Cell , accurately reflects the cellular phenotypes, providing data to understand how many genetic changes affect human brain development.

NDDs are present in approximately 25% of all chronic pediatric disorders, collectively imposing an enormous toll, accounting for over $400 billion in annual U.S. healthcare costs and lost wages. Affecting more than four percent of children, NDDs span an enormous diagnostic and genetic landscap

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