Only one weekend of games remains before the 12-team College Football Playoff bracket is set on Sunday, Dec. 7, but there's still plenty of potential shakeup in the cards.

A handful of programs are in action in Week 15, with a few teams looking to play themselves into the CFP, especially at the non-Power Four level. The winner of the American championship game between North Texas and Tulane is likely to find themselves at the back end of the playoff.

BYU could also play itself into the CFP, if it can avenge its loss to Texas Tech earlier in the season in the Big 12 championship game. A Cougars win would likely steal a bid from Notre Dame or Alabama, should the Crimson Tide fall to Georgia in the SEC championship game.

Suffice to say, there's still plenty to learn about which teams will be playing for a national championship this season.

Here are USA TODAY Sports' predictions and picks for each top-25 matchup in conference championship week, including betting odds.

College football Week 15 predictions, picks, odds

Odds courtesy of BetMGM as of Thursday, Dec. 4.

No. 1 Ohio State vs. No. 2 Indiana

  • Time: 8 p.m. ET
  • Date: Saturday, Dec. 6
  • TV: Fox
  • Spread: Ohio State (-4)
  • Prediction: Ohio State 27, Indiana 21

No. 3 Georgia vs. No. 10 Alabama

  • Time: 4 p.m. ET
  • Date: Saturday, Dec. 6
  • TV: ABC
  • Spread: Georgia (-2.5)
  • Prediction: Georgia 31, Alabama 27

No. 6 Texas Tech vs. No. 11 BYU

  • Time: Noon ET
  • Date: Saturday, Dec. 6
  • TV: ABC
  • Spread: Texas Tech (-12.5)
  • Prediction: Texas Tech 31, BYU 14

No. 16 Virginia vs. Duke

  • Time: 8 p.m. ET
  • Date: Saturday, Dec. 6
  • TV: ABC
  • Spread: Virginia (-4.5)
  • Prediction: Virginia 31, Duke 23

Troy at No. 19 James Madison

  • Time: 7 p.m. ET
  • Date: Friday, Dec. 5
  • TV: ESPN
  • Spread: James Madison (-23.5)
  • Prediction: James Madison 42, Troy 20

No. 20 North Texas at No. 21 Tulane

  • Time: 8 p.m. ET
  • Date: Friday, Dec. 5
  • TV: ABC
  • Spread: North Texas (-2.5)
  • Prediction: North Texas 42, Tulane 38

This article originally appeared on USA TODAY: College football Week 15 picks, predictions, odds for every top-25 matchup

Reporting by Austin Curtright, USA TODAY NETWORK / USA TODAY

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