The Week 15 NFL schedule for the 2025 season brings some exciting matchups.

The Chargers seek their first sweep over the Chiefs since 2013, the Patriots can clinch the AFC East title with a win Sunday, and two of the best defenses in the league -- Green Bay and Denver -- will battle it out. We could also see 44-year-old Philip Rivers make his Colts debut, as well as rookie QB Brady Cook 's first start forthe Jets.

We have you covered with everything you need to know. Our NFL Nation reporters take you inside the locker room with the best thing they heard this week, and ESPN Research provides a key stat to know and a betting nugget for each contest. Plus, analytics writer Seth Walder makes a bold prediction for each matchup, and fantasy analyst Eric Moody shares fantasy football

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