Sarah Sherman ’s debut comedy special is titled “Live + In the Flesh.” But she’s also in blood, guts, goo and a heap of NSFW prosthetics.

At the beginning of the hour, which debuts Dec. 12 on HBO, Sherman coalesces from a skull inside a pile of mush and eyeballs and glitter as John Waters, playing a stage manager, looks at her in disgust: “Go on out there and remind them why God invented the barf bag.”

Sherman is best known for “Saturday Night Live,” where she plays oddball characters and straight women alike, all while being a frequent tormenter of Colin Jost behind the “Weekend Update” desk. But “Live + In the Flesh” is billed as a special from Sarah Squirm , her body-horror alter ego, and Sherman sure takes advantage of her hour away from NBC’s standards and practices.

Ahead of th

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