Two of the league's worst teams square off in Week 15 of the 2025 NFL season when the Washington Commanders visit the New York Giants. The Commanders and Giants have failed in large part due to injuries, though Washington's fall has been much more severe after its run to the NFC Championship Game last season. Washington is on an eight-game losing streak while New York has lost seven in a row.

Kickoff from MetLife Stadium in East Rutherford, New Jersey is set for 1 p.m. ET. The Giants are 2.5-point favorites in the latest Commanders vs. Giants odds at DraftKings , while the over/under is 46.5. Before making any Giants vs. Commanders picks of your own, make sure to look at the top NFL picks from the SportsLine Projection Model, which simulates every NFL game 10,000 times.

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