The NFL preseason is in the books and now all the focus turns to the Week 1 NFL schedule. It's another strong opening slate that begins with Cowboys vs. Eagles in the 2025 NFL Kickoff Game next Thursday, followed by Chiefs vs. Chargers in Brazil on Friday. Thirteen games are on the Sunday schedule, with Vikings vs. Bears wrapping it up on Monday. NFL bettors are often targeting spreads, totals and money-line NFL picks. Some key Week 1 NFL odds include the Eagles at -7 against the Cowboys and the Chiefs at -3 against the Chargers. The Ravens, meanwhile, are -1.5 against the Bills in a Sunday Night Football showdown between AFC contenders.

A set of exact Week 1 NFL score predictions can give you the tools needed to make a variety of picks for every game, as well as a guide for some NFL prop

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