After a four-game FBS appetizer in Week 0, the 2025 college football season kicks into high gear over Labor Day Weekend. There are college football games every day from Thursday to Monday, including some of the most anticipated showdowns of the season. It's an absolutely loaded Week 1 college football odds board that leaves bettors with almost endless opportunities to lock in their college football best bets.

Preseason Heisman favorite Arch Manning leads No. 1 Texas as a 1.5-point underdog against Jeremiah Smith and No. 3 Ohio State, No. 8 Alabama is -13.5 vs. Florida State and No. 4 Clemson is -3.5 against No. 9 LSU. Those are just a few of the top college football lines to consider in what is the top non-conference slate of the season. Before locking in any college football picks for We

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