College football fans can almost taste it. The 2025 season is officially back this Saturday with a full slate of games, headlined by No. 1 Texas heading to Columbus to take on No. 3 Ohio State . The Longhorns are 2.5-point underdogs despite having the higher ranking, and are a popular pick to upset the defending national champions. However, are they the among the underdogs with the most betting value in Week 1?

The Inside the Lines team -- which powers the SportsLine model -- has simulated every game to find its favorite underdog plays for Week 1. For more free plays, you can find daily best bets on the Inside the Lines Blog .

College Football Week 1 Best Underdog Bets

LSU (+150, DraftKings) @ Clemson

Model: LSU 33, Clemson 30

We like LSU outright against Clemson. Both progra

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