Key takeaways:

Hemodiafiltration is a promising candidate to improve in-center dialysis outcomes.

Yet data have not shown improvement in quality of life or hospitalization rates.

Achieving widespread use may be challenging.

Improving outcomes for patients requiring kidney replacement therapy remains one of the most complex and persistent challenges in modern medicine.

Despite strong consensus that kidney transplantation provides superior survival and quality of life for eligible patients, the stark reality is that most individuals with end-stage kidney disease are consigned to life-sustaining dialysis due to a chronic shortage of donor organs and the high up-front risks associated with transplantation.

Home-based dialysis, particularly more frequent and longer treatments, has long sh

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