The Week 1 college football schedule brings dozens of intriguing matchups that will shape the early College Football Playoff picture. Games started on Thursday and continue Friday through Monday, highlighted by three ranked matchups involving top-10 teams with Texas vs. Ohio State (-1), LSU vs. Clemson (-4) and Notre Dame vs. Miami (+2.5). Those college football spreads are all within a touchdown, but there are also some giants numbers on the Week 1 college football odds board as some teams are starting out with easier opponents.

Indiana is a 23.5-point favorite over Old Dominion, per the Week 1 college football spreads, while Texas A&M is favored by 23.5 points over UTSA. Those are among a handful of games with Week 1 college football spreads of at least 20 points. Making college footbal

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