Key takeaways:

Aspirin use increased risk in patients with chronic coronary syndrome on oral anticoagulation.

The AQUATIC trial was stopped early due to excess deaths in the aspirin group.

Perspective from Deepak L. Bhatt, MD, MPH

In patients with chronic coronary syndrome on long-term oral anticoagulation, use of aspirin was linked with increased risk for ischemic events, bleeding and death, researchers reported at the European Society of Cardiology Congress.

For the AQUATIC trial, simultaneously published in The New England Journal of Medicine , Martine Gilard , MD, PhD, FESC, director of the interventional cardiology department at Brest Hospital University, France, and colleagues randomly assigned 822 patients with chronic coronary syndrome who had undergone stent implan

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