The Week 1 NFL schedule is approaching and the league has again spread it out over four different days. The latest Week 1 NFL odds list the Eagles at -7.5 against the Cowboys in the 2025 NFL Kickoff Game on Thursday, Sept. 4. The Chiefs are -3 against the Chargers in Brazil on Friday. Thirteen other games are set for that Sunday, with Bears (-1.5) vs. Vikings concluding the slate on Monday Night Football. The highest total of the Week 1 NFL schedule is 50.5 points in Ravens vs. Bills on Sunday Night Football.

Effectively building NFL parlay picks can pay off big in your NFL betting strategy. NFL parlays come with a much greater risk than straight bets, but they also carry the potential of a much bigger reward. Before making any Week 1 NFL picks and parlays, you need to see the Week 1 NFL

See Full Page