The Kansas City Chiefs and Los Angeles Chargers will open their 2025 NFL seasons in Sao Paulo, Brazil, on Friday. Chargers vs. Chiefs marks the second straight season the NFL will play a Week 1 Friday night game in Brazil. The Chiefs enter after winning their fifth AFC Championship over the last six years. However, Kansas City lost 40-22 to the Eagles in the big game after a 15-2 season. The Chargers went 11-6 and lost to the Texans, 32-12, in the Wild Card round last year.

Kickoff is set for 8 p.m. ET on Friday from Neo Química Arena in Sao Paulo, Brazil. The Chiefs are favored by 3 points in the latest Chargers vs. Chiefs odds at FanDuel Sportsbook, with the over/under set at 46.5 points. Before making any Chiefs vs. Chargers picks, make sure you check out the NFL picks from the SportsL

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