The Week 2 college football schedule arrives on Friday, and now bettors must decide how to react to the Week 1 results. Ohio State, TCU, LSU and Florida State were among the teams that made a statement over Labor Day Weekend. Ohio State, LSU and FSU get easier Week 2 opponents, while TCU is off following its blowout win on Monday over Bill Belichick and UNC.

Some of the Week 2 college football odds of note include Oklahoma (-5.5) against Michigan, Oregon (-28.5) against Oklahoma State and Ole Miss (-10) against Kentucky. Before locking in any college football picks for Week 2 of the 2025 season for those games or others, be sure to see the college football betting guide from legendary Vegas handicapper Bruce Marshall .

For years Vegas-based Marshall was synonymous with The Gold Sheet,

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