Key Takeaways

A shorter run of penicillin treatment can clear up syphilis, clinical trial results show

One dose of benzathine penicillin G worked as well as the usual three-dose regimen to treat early syphilis

A one-dose treatment plan could help with ongoing drug shortages and limit the development of antibiotic resistance

THURSDAY, Sept. 4, 2025 (HealthDay News) — A single dose of penicillin works just as well to cure early syphilis as the three-injection regimen now used by many doctors, a new clinical trial says.

Second and third doses of benzathine penicillin G (BPG) don’t provide any additional benefit in treating early-stage syphilis, researchers reported in the New England Journal of Medicine .

“Benzathine penicillin G is highly effective against syphilis, but the thr

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