The 2025 NFL season kicks off Thursday night, so it's time to lock in any Week 1 NFL survivor picks. In 2024, there was a stunner right off the bat as the New England Patriots upset the Cincinnati Bengals in Week 1, knocking many NFL survivor players out of their pools before even reaching Week 2. NFL survivor strategy does involve thinking about what's down the road, but advancing past Week 1 in NFL knockout pools is the first objective.

The latest Week 1 NFL odds show five games with a spread of 5.5 points or more. Those are the games most NFL survivor players will be targeting, but among those favorites, which ones bring the most value in NFL survivor pools? Before finalizing any Week 1 NFL survivor picks, see which team the red-hot SportsLine Projection Model just went all-in on .

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