We're finally here. Week 1 of the 2025 NFL season … and it's packed with storylines. To better understand and decipher those storylines, NFL Pro has a wealth of data and insights, carefully curated to highlight what matters most in each game. And in the world of fantasy football, we need every advantage we can get.

Here are five of those storylines, with all the relevant NFL Pro insights and the fantasy fallout we can expect on Opening Weekend.

Chris Jones, Chiefs front vs. Chargers O-line without Rashawn Slater

In a special Friday showdown in Sao Paulo, Brazil, the defending AFC Champion Chiefs are taking on the Chargers at Arena Corinthians. Arguably the most critical matchup of the game will be the Chiefs' pass rush against L.A.'s offensive line … especially after the loss of Pro

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