Kansas City Chiefs quarterback Patrick Mahomes (15) talks with coach Andy Reid after a play against the Chicago Bears during a preseason game at GEHA Field at Arrowhead Stadium in Kansas City, Missouri.

The Kansas City Chiefs face the LA Chargers Friday in Sao Paulo, Brazil, for the second game of the NFL season. Kickoff from Corinthians Arena is at 8 p.m. ET (NFL+ / YouTube). Let's analyze BetMGM Sportsbook's NFL odds around the Chiefs vs. Chargers odds and make our expert NFL picks and predictions for the best bets.

The Chiefs are coming off a third consecutive Super Bowl, but lost 40-22 to the Philadelphia Eagles. They shored up their hole at left tackle selecting Josh Simmons in the first round out of Ohio State. The main playmakers for QB Patrick Mahomes return — TE Travis Kelce and WRs Xavier Worthy, Hollywood Brown and JuJu Smith-Schuster, with Isiah Pacheco at running back.

The Chargers, the designated home team for this game, are coming off a playoff appearance and an 11-win season in Jim Harbaugh's first year as coach. They added RB Najee Harris in free agency and RB Omarion Hampton in the 2025 NFL draft. They lost LT Rashawn Slater for the season in training camp, so Joe Alt moves left tackle and Trey Pipkins takes over at right tackle.

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Chiefs vs. Chargers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:58 a.m. ET.

  • Moneyline (ML): Chiefs -175 (bet $175 to win $100) | Chargers +145 (bet $100 to win $145)
  • Against the spread (ATS): Chiefs -3 (-118) | Chargers +3 (-102)
  • Over/Under (O/U): 46.5 (O: -110 | U: -110)

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Chiefs vs. Chargers key injuries

Chiefs

  • DL Omar Norman-Lotts (ankle) questionable
  • WR Jalen Royals (knee) out

Chargers

  • None

Chiefs vs. Chargers picks and predictions

Prediction

Chiefs 28, Chargers 24

Moneyline

The Chiefs have a 7-game winning streak against the Chargers and allowed a total of 27 points to them in 2 games last season.

The Chargers went 2-3 in prime-time games last season, while the Chiefs went 5-0 in prime time last season. Mahomes in a nationally televised game in prime time? Some heroes will be coming.

Now, -175 isn't bad, but you get better value from the spread.

PASS.

Against the spread

The Chiefs started hot last season, covering the spread in 5 of their first 6 games. They did not cover the 2.5-point spread in their 19-17 win over the Chargers in their second matchup of the season.

The Chargers were 12-6 ATS last season.

The Chiefs look like largely the same team that went to the Super Bowl for the third consecutive year. Don't bet against Mahomes, especially early in the season.

BET CHIEFS -3 (-118).

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Over/Under

The last 3 meetings for the Chiefs and Chargers have not even reached 40 total points.

However, including the postseason, the Chiefs' final 5 games and 7 of their final 8 had more than 46 total points. The Chargers' final 6 games had more than 46 total points.

BET OVER 46.5 (-110).

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This article originally appeared on Sportsbook Wire: Kansas City Chiefs vs. LA Chargers odds, picks and predictions

Reporting by Jess Root, Sportsbook Wire / Sportsbook Wire

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