On paper, Week 2 may not be as alluring as the first week of the 2025 college football season. There's just one game featuring two ranked teams and some of the most prominent programs in America are playing tune-up games against FCS opponents before conference play begins.

That doesn't mean it entirely lacks intriguing matchups. College Football Playoff competitors like No. 11 Illinois have to travel to face off against tough Power Four competition, while Saturday's prime-time game between No. 15 Michigan and No. 18 Oklahoma pits two of the sport's most iconic brands against one another.

There's also a couple of intriguing rivalries featured during the Week 2 slate, one of which includes a ranked Big 12 contender in No. 16 Iowa State . College football Week 2 storylines:

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