Week 2 of the college football season kicks off with the Louisville Cardinals (1-0) hosting the James Madison Dukes (1-0) on Friday. The Cardinals (9-4, 5-3 in ACC in 2024) head into their second home game of the season after dominating Eastern Kentucky, 51-17, to kick off the 2025 season. They welcome Sun Belt competitor James Madison (9-4, 4-4 in 2024), who defeated Weber State, 45-10, in their season debut.

Kickoff from L&N Stadium in Louisville is set for 7 p.m. ET. The Cardinals are 15.5-point favorites in the latest James Madison vs. Louisville odds from SportsLine consensus, while the over/under for total points scored is 54.5. Before making any Louisville vs. James Madison picks, make sure you check out the college football picks from the SportsLine projection model. New users

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