No. 18 Iowa State football hosts rival Iowa for the 2025 Cy-Hawk game at Jack Trice Stadium at 11:10 a.m. CT Saturday, Sept. 6. FOX will televise the contest.

The Cyclones (2-0) are coming off a dominant 55-7 victory over South Dakota in their home opener. The Hawkeyes (1-0) beat Albany 34-7 in their season opener.

Here's some predictions of how several experts believe the Iowa State -Iowa matchup will go. Stream Iowa State vs. Iowa free with Fubo

Iowa State vs. Iowa odds, money line, over/under

Odds courtesy of BetMGM as of Friday, Sept. 5. Expert MLB daily picks: Unique MLB betting insights only at USA TODAY

Spread : Iowa State -3.5

Moneyline: Iowa State -170, Iowa +145

Over/under : 42.5

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