Aug 29, 2025; Champaign, Illinois, USA; Illinois Fighting Illini quarterback Luke Altmyer (9) runs the ball against the Western Illinois Leathernecks during the first half at Memorial Stadium. Mandatory Credit: Ron Johnson-Imagn Images

Illinois hits the road on Saturday afternoon to take on Duke in a must-win game. The loss won't kill the Fighting Illini's season, but they have playoff aspirations and they need to beat the Blue Devils on the road. The schedule sets up nicely for the Fighting Illini to make a run, though.

The Blue Devils have been overlooked in the ACC, but they are looking to show they are ready to compete. Getting a win on Saturday will put them on the map. They have a tough road game next weekend against Tulane, but first want to send Illinois home with a loss.

Stream Duke vs. Illinois

If you're looking to get back in the swing of football season and need some betting advice for Saturday's matchup in Durham, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Duke vs. Illinois game odds:

All college football odds via BetMGM.

  • Spread: Illinois -3 (-115), Duke +3 (-105)
  • Money Line: Illinois -155, Duke +130
  • Over-Under: Over 49.5 (-110), Under 49.5 (-110)

Duke vs. Illinois prediction, pick:

The Fighting Illini get their first real test of the year and they need to win this game if they want to make a run at the playoffs. The Blue Devils, though, are a pesky team and very capable of picking up the upset. Luke Altmyer isn't the flashiest of quarterbacks, but he is effective and that will be enough to give the Illini a big road win on Saturday.

Prediction: Illinois 24, Duke 17

Best Bet: Illinois money line, Under 49.5

Duke vs. Illinois channel, start time, streaming:

Time: 12 p.m. ET

TV Channel: ESPN

Live Stream: ESPN App

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Duke vs. Illinois: Week 2 College Football Betting Odds, Prediction, Pick

Reporting by Adam Childs, College Sports Wire / College Sports Wire

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