The Week 1 NFL schedule continues Sunday, and some of the tightest NFL odds include Rams vs. Texans (+3), Packers vs. Lions (+2.5) and 49ers vs. Seahawks (+1.5). There are just two contests with Week 1 NFL spreads of over a touchdown, including when No. 1 overall pick Cam Ward makes his pro debut as his Titans are 8.5-point underdogs to the Broncos, making them the biggest NFL underdog left on the board this weekend. Whatever NFL betting trends you decide to follow for the opening slate of games, you certainly want your football bets to kick off the 2025 NFL season to start off on the right note.

All of the updated Week 1 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 1 NFL picks now

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