John Nestor had a pick-six on the game's first offensive play and Minnesota scored five first-quarter touchdowns en route to overwhelming FCS Northwestern State 66-0 Saturday.
With severe weather in the area, the game ended with 6:15 left in the fourth quarter.
Minnesota amassed 484 yards of offense and scored its most points in a game since 2001.
"We knew it was about us this afternoon. We knew we had to start fast, accelerate in the middle and finish strong. Our players accomplished that," coach P.J. Fleck said.
Drake Lindsey was 8 of 9 for 139 yards in his five series. Nine receivers had catches and 10 running backs had carries, led by Grant Washington's 126 yards.
However, Minnesota's top ballcarrier left the game early with an apparent injury.
Darius Taylor ran out of bounds and