A division as difficult as the NFC West has become cannot be won in Week 1. But winning or losing the first divisional matchup of the season can go a long way towards hopes of a division title being made or broken.

Such is the challenge faced by the San Francisco 49ers and the Seattle Seahawks , who are once again pitted in what is expected to be one of pro football's toughest divisions in 2025. With the Los Angeles Rams coming off of an NFC West title in 2024 after a tight battle with the 49ers, Seahawks and Arizona Cardinals , there is little margin for error with any team in the NFL's incubator of new-age, West Coast football.

After a down year plagued by injuries, the 49ers will try to take the NFC West crown back in 2025 and reach the Super Bowl for the third time in coa

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