Breaking down 49ers’ schedule: A look at the Niners’ season from Week 1 through 18

Here is a week-by-week look at the 49ers’ 2025 schedule as they try to return to the playoffs and make another Super Bowl run

Week 1: Sunday, Sept. 7 (1:05 p.m., FOX)

at Seattle Seahawks

Sam Darnold’s Seahawks debut comes against a rebuilt 49ers’ defense with Robert Saleh reprising his role as coordinator after four years as the Jets’ head coach. Linebacker Fred Warner and the run defense will get a firm test out the gate to see if it’s improved enough to thwart Kenneth Walker III. If Brock Purdy improves to 3-0 all-time in Seattle, critics of his contract extension will be silenced – for a week. If Christian McCaffrey is available for this opener, then the 49ers already will be off to a better start than last year.

Week 2: Sunday, Sept. 14 (10 a.m., FOX)

at New Orleans Saints

A week