No team performed worse against the spread (ATS) than the Titans in 2024 as they went just 2-15. Meanwhile, no team had more ATS victories than the Broncos' 12, and it just so happens that you can make Week 1 NFL picks on Titans vs. Broncos. Denver is an 8.5-point favorite, per the latest Week 1 NFL odds , making Bo Nix and the Broncos the largest remaining favorite of the opening slate as number one overall pick, Cam Ward, will debut against the team that led the NFL in sacks last year. Should you expect these NFL betting trends to carry over into a new season?

Other games with NFL lines of 5 or more points include Bengals vs. Browns (+5.5), Saints vs. Cardinals (-6) and Giants vs. Commanders (-6.5). Meanwhile, the slimmest of the Week 1 spreads is Dolphins vs. Colts (-1). If you are l

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