The first Sunday Night Football game of the 2025 NFL season promises to be an exciting one as the Buffalo Bills host the Baltimore Ravens . Buffalo has won three of the last four head-to-head meetings with Baltimore, including a 27-25 win at home in last season's Divisional Playoffs. However, Baltimore defeated Buffalo, 35-10, in a Week 4 contest last season. The Bills finished last year atop the AFC East at 13-4 record, and the Ravens topped the AFC North at 12-5. Buffalo was 4-1 against the spread in primetime last season, while Baltimore has covered in five straight regular-season games versus the Bills.

Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 8:20 p.m. ET. Baltimore is a 1.5-point favorite in the latest Ravens vs. Bills odds, after Buffalo opened as 1.5-poi

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