Rosie O’Donnell is opening up about the end of her friendship with fellow talk show host, Ellen DeGeneres.

“Instead of deciding to stand next to me and hold my hand, which is what I did to her, she did the opposite,” O’Donnell said during the Sunday, September 7, episode of Mamamia’s “No Filter” podcast. “That was, like, one of the most painful things that ever happened to me, in show business, in my life.”

O’Donnell and DeGeneres’ falling out reportedly occurred after the Finding Nemo star made a comment about her dynamic with O’Donnell during a 2004 appearance on Larry King Live.

“I don’t really know Rosie that well. I mean, I’ve spoken to her, but we’re not really friends,” she told the host at the time.

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