Sep 7, 2025; New Orleans, Louisiana, USA; Arizona Cardinals running back James Conner (6) dodges New Orleans Saints linebacker Pete Werner (20) during the first quarter at Caesars Superdome. Mandatory Credit: Stephen Lew-Imagn Images
Sep 7, 2025; Denver, Colorado, USA; Denver Broncos running back J.K. Dobbins (27) after the game at Empower Field at Mile High. Mandatory Credit: Ron Chenoy-Imagn Images
Sep 7, 2025; East Rutherford, New Jersey, USA; Pittsburgh Steelers running back Jaylen Warren (30) scores a touchdown in front of Pittsburgh Steelers linebacker Carson Bruener (44) during the game at MetLife Stadium. Mandatory Credit: Vincent Carchietta-Imagn Images
Aug 22, 2025; Kansas City, Missouri, USA; Kansas City Chiefs running back Isiah Pacheco (10) runs the ball during the first half against the Chicago Bears at GEHA Field at Arrowhead Stadium. Mandatory Credit: Jay Biggerstaff-Imagn Images
Sep 7, 2025; Inglewood, California, USA; Los Angeles Rams safety Kam Curl (3) and Los Angeles Rams linebacker Omar Speights (48) tackle Houston Texans running back Nick Chubb (21) during the fourth quarter at SoFi Stadium. Mandatory Credit: Kiyoshi Mio-Imagn Images
Aug 8, 2025; Foxborough, Massachusetts, USA; New England Patriots running back Rhamondre Stevenson (38) runs against the Washington Commanders during the first half at Gillette Stadium. Mandatory Credit: Brian Fluharty-Imagn Images

This weekend in the NFL will feature some running backs who should be primed to have great days for your fantasy football roster. Let's take a look at who you should start, and who you should sit during the NFL's week 2 slate of games.

Start - James Conner, RB, Arizona Cardinals

The Arizona Cardinals will be taking on a Carolina Panthers team that gives up a ton of touchdowns to opposing running backs. In fact, in their last three games, the Panthers have allowed at least 18 PPG to the other teams' running backs. No team has allowed more points to running backs than the Panthers dating back to the start of last season.

Start - J.K. Dobbins, RB, Denver Broncos

J.K. Dobbins is looking like he will be the feature back in Denver. Dobbins and the Broncos are scheduled to play the Indianapolis Colts, who have given up 15-plus points to running backs dating back to last season. Even though the Colts would beat the Miami Dolphins pretty handily the previous weekend, they gave up over 16 points to Miami Dolphins running back De'Von Achane. Dobbins will split time, but he would see more touches and points last weekend for Denver.

Start - Jaylen Warren, RB, Pittsburgh Steelers

Jaylen Warren had 11 carries last week for 37 yards and two catches for 22 yards. He did score a touchdown, making him worth the start during week one. Look for Warren's production to increase versus a Seattle Seahawks defense that played pretty stingy for the most part in a loss against the San Francisco 49ers.

Sit - Isiah Pacheco, RB, Kansas City Chiefs

From a fantasy points perspective, Pacheco has become primarily a 3rd or 4th back off the bench in most leagues since he suffered a broken leg in week two of last season. Pacheco only saw seven touches in the loss to the Los Angeles Chargers, and just cannot be trusted right now with anything other than depth.

Sit - Nick Chubb, RB, Houston Texans

I didn't see enough out of Chubb to warrant a start in leagues for right now. He wasn't bad, scoring just over six fantasy points, but he never caught a pass out of the backfield, which is a considerable part of his game. I would sit him this week against a stout Tampa Bay Buccaneers defense that has given up the least amount of points to running backs dating back to the beginning of last season.

Sit - Rhamondre Stevenson, RB, New England Patriots

It appears that the Patriots do not necessarily know who they want to handle the majority of the carries just yet. By the numbers, rookie TreVeyon Henderson touched the ball more in the game against the Las Vegas Raiders. Still, Stevenson was ineffective with only seven carries out of the backfield for a total of 15 yards. Henderson would have five more catches out of the backfield, possibly solidifying a future slide up the depth chart.

This article originally appeared on Touchdown Wire: Fantasy Football Week 2 Start 'Em & Sit 'Em Running Back Edition

Reporting by Josh Petry, Touchdown Wire / Touchdown Wire

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